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東京大学大学院農学生命科学研究科分子育種学研究室

研究業績

論文発表　　学会等での受賞

論文発表

    23. RNase T2-involved selective autophagy of ribosomes induced by starvation in yeast.
    Minami A, Nishi K, Yamada R, Jinnai G, Shima H, Oishi S, Akagawa H, Aono T, Hidaka M, Masaki H, Kuzuyama T, Noda Y, Ogawa T*.
    bioRxiv. 2023 doi: 10.1101/2023.07.14.548783.

    22. Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin.
    Hibi G, Shiraishi T, Umemura T, Nemoto K, Ogura Y, Nishiyama M, Kuzuyama T*.
    Nat Commun. 2023 Dec 6;14(1):8065. doi: 10.1038/s41467-023-43731-z.

    21. Dethiobiotin uptake and utilization by bacteria possessing bioYB operon.
    Ikeda T, Ogawa T, Aono T*.
    Res Microbiol. 2023 Nov-Dec;174(8):104131. doi: 10.1016/j.resmic.2023.104131.

    20. Substrate Recognition Mechanism of a Trichostatin A-Forming Hydroxyamidotransferase.
    Nagata R*, Nishiyama M, Kuzuyama T*.
    Biochemistry 2023 Jun 20;62(12):1833-1837. doi: 10.1021/acs.biochem.3c00025.
    Selected as Front Cover Art!
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    19. Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C–C Bond.
    Zhu Y, Shiraishi T, Lin J, Inaba K, Ito A, Ogura Y, Nishiyama M, Kuzuyama T*.
    J Am Chem Soc. 2022 Sep 21;144(37):16715-16719. doi: 10.1021/jacs.2c06546.
    This article was introduced in "Hot of the press"(Natural Product Reports)

    18. Cryptic Oxidative Transamination of Hydroxynaphthoquinone in Natural Product Biosynthesis.
    Noguchi T, Isogai S, Terada T, Nishiyama M, Kuzuyama T*.
    J Am Chem Soc. 2022 Mar 30;144(12):5435-5440. doi: 10.1021/jacs.1c13074.
    press release

    17. Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-like Enzymes.
    Nagata R, Suemune H, Kobayashi M, Shinada T, Shin-ya K, Nishiyama M, Hino T, Sato Y, Kuzuyama T*, Nagano S*.
    Angew Chem Int Ed Engl. 2022 Mar 9:61(20):e202117430. doi: 10.1002/anie.202117430.
    press release

    16. Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A-94964.
    Shao X, Zheng C, Xu P, Shiraishi T, Kuzuyama T, Molinaro A, Silipo A, Yu B.
    Angew Chem Int Ed Engl. 2022 Mar 28;61(14):e202200818. doi: 10.1002/anie.202200818.

    15. Biosynthesis of the nucleoside antibiotic angustmycins: identification and characterization of the biosynthetic gene cluster reveal unprecedented dehydratase required for exo-glycal formation.
    Shiraishi T, Xia J, Kato T, Kuzuyama T.*
    J Antibiot. 2021 Nov;74(11):830-833. doi: 10.1038/s41429-021-00466-7.

    14. A novel oxazole-containing tetraene compound, JBIR-159, produced by heterologous expression of the cryptic trans-AT type polyketide synthase biosynthetic gene cluster.
    Hashimoto T, Hashimoto J, Kagaya N, Nishimura T, Suenaga H, Nishiyama M, Kuzuyama T, Shin-ya K.*
    J Antibiot. 2021 May;74(5):354-358. doi: 10.1038/s41429-021-00410-9.

    13. Biosynthetic pathways and enzymes involved in the production of phosphonic acid natural products.
    Shiraishi T, Kuzuyama T.*
    Biosci Biotechnol Biochem. 2021 Jan 7;85(1):42-52. doi: 10.1093/bbb/zbaa052.
    Selected as a cover picture!

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    12. Reconstitution of a Highly Reducing Type II PKS System Reveals 6π-Electrocyclization Is Required for o-Dialkylbenzene Biosynthesis.
    Zhang J, Yuzawa S, Thong WL, Shinada T, Nishiyama M, Kuzuyama T.*
    J Am Chem Soc. 2021 Fub 24;143(7):2962-2969. doi: 10.1021/jacs.0c13378.
    press release

    11. Substrate recognition mechanism of tRNA-targeting ribonuclease, colicin D, and an insight into tRNA cleavage-mediated translation impairment.
    Ogawa T, Takahashi K, Ishida W, Aono T, Hidaka M, Terada T, Masaki H.*
    RNA Biol. 2021 Aug;18(8):1193-1205. doi: 10.1080/15476286.2020.1838782.
    press release

    biomolecules2020

    10. Recent advances in the biosynthesis of nucleoside antibiotics.
    Shiraishi T, Kuzuyama T.*
    J Antibiot. 2019 Dec;72(12):913-923. doi: 10.1038/s41429-019-0236-2.

    9. An Unusual Skeletal Rearrangement in the Biosynthesis of the Sesquiterpene Trichobrasilenol from Trichoderma.
    Murai K,† Lauterbach L,† Teramoto K, Quan Z, Barra L, Yamamoto T, Nonaka K, Shiomi K, Nishiyama M, Kuzuyama T,* Dickschat JS.*
    Angew Chem Int Ed Engl. 2019 Aug 16. doi: 10.1002/anie.201907964.

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    8. An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces.
    Kobayashi M, Tomita T, Shin-ya K, Nishiyama M, Kuzuyama T.*
    Angew Chem Int Ed Engl. 2019 Jul 26. doi: 10.1002/anie.201906864.

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    7. Biochemical characterization of archaeal homocitrate synthase from Sulfolobus acidocaldarius.
    Suzuki T, Akiyama N, Yoshida A, Tomita T, Lassak K, Haurat MF, Okada T, Takahashi K, Albers SV, Kuzuyama T, Nishiyama M.*
    FEBS Lett. 2019 Jul 22. doi: 10.1002/1873-3468.13550.

    6. Comprehensive Derivatization of Thioviridamides by Heterologous Expression.
    Kudo K, Koiwai H, Kagaya N, Nishiyama M, Kuzuyama T, Shin-ya K, Ikeda H.*
    ACS Chem Biol. 2019 Jun 21;14(6):1135-1140. doi: 10.1021/acschembio.9b00330.

    5. The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics.
    Romo AJ,† Shiraishi T,† Ikeuchi H, Lin GM, Geng Y, Lee YH, Liem PH, Ma T, Ogasawara Y, Shin-ya K, Nishiyama M, Kuzuyama T,* Liu HW.*
    J Am Chem Soc. 2019 May 31. doi: 10.1021/jacs.9b03021.

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    4. Glutamate Dehydrogenase from Thermus thermophilus Is Activated by AMP and Leucine as a Complex with Catalytically Inactive Adenine Phosphoribosyltransferase Homolog.
    Tomita T, Matsushita H, Yoshida A, Kosono S, Yoshida M, Kuzuyama T, Nishiyama M.*
    J Bacteriol. 2019 Jun 21;201(14). pii: e00710-18. doi: 10.1128/JB.00710-18.

    3. Protein acetylation on 2-isopropylmalate synthase from Thermus thermophilus HB27.
    Yoshida A, Yoshida M, Kuzuyama T, Nishiyama M, Kosono S.*
    Extremophiles. 2019 Jul;23(4):377-388. doi: 10.1007/s00792-019-01090-y.

    2. Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway.
    Shiraishi T, Nishiyama M, Kuzuyama T.*
    Org Biomol Chem. 2019 Jan 16;17(3):461-466. doi: 10.1039/c8ob02765j.

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    1. Structural and Mechanistic Insight into Terpene Synthases that Catalyze the Irregular Non-Head-to-Tail Coupling of Prenyl Substrates.
    Kobayashi M, Kuzuyama T.*
    Chembiochem. 2019 Jan 2;20(1):29-33. doi: 10.1002/cbic.201800510.

学会等での受賞

    2024/03/22
    倉本 泰遥(B4)　令和5年度東京大学農学部　学部長賞
    2024/03/21
    日比 玄紀(D3)　令和5年度東京大学大学院農学生命科学研究科　研究科長賞
    2023/09/29
    尉 嘉眙(D2)　第33回イソプレノイド研究会例会　奨励賞
    2023/09/07
    白石 太郎(助教)　2023年度日本放線菌学会　浜田賞
    2023/07/07
    南 篤(D3)　第24回日本RNA学会年会　年会長特別賞
    2023/03/14
    朱 裕勋(D2)　日本農芸化学会2023年度大会　トピックス賞
    2022/09/29
    南 篤(D2)　第60回日本生物物理学会年会　シンポジウム演題採択
    2022/09/16
    朱 裕勋(D2)　2022年度日本放線菌学会大会　ポスター発表賞
    2022/09/16
    朱 裕勋(D2)　2022年度日本放線菌学会大会　ポスター発表賞
    2022/08/27
    日比 玄紀(D2)　日本農芸化学会関東支部2022年度大会　優秀発表賞
    2022/06/30
    朱 裕勋(D2)　4th Global Innovation Workshop　Outstanding Presentation Award
    徐 昊(M2)　4th Global Innovation Workshop　Poster Award
    2022/03/17
    日比 玄紀(D1)　日本農芸化学会2022年度大会　トピックス賞
    2021/11/05
    野口 智弘(D3)　第63回天然有機化合物討論会　奨励賞
    2021/09/18
    湯澤 賢(共同研究員)　2021年度日本放線菌学会　浜田賞
    2021/08/28
    野口 智弘(D3)　2021年度日本農芸化学会関東支部大会　優秀発表賞
    2020/11/10
    南 篤(M2)　2nd Global Innovation Workshop　Outstanding Presentation Award
    2020/10/30
    吉留 大輔(D3)　第20回東京大学生命科学シンポジウム　優秀ポスター賞